0001006281 2022-06-30 0001006281 2023-04-30 0001006281 2022-01-01 2022-12-31 shares iso4217:USD 0001006281 --12-31 2022 FY false 10-K/A true 2022-12-31 false 001-33357 PROTALIX BIOTHERAPEUTICS, INC. DE 65-0643773 2 University Plaza Suite 100 Hackensack NJ 07601 201 696-9345 Common stock, $0.001 par value PLX NYSEAMER No No Yes Yes Non-accelerated Filer true false false false 52200000 65414917 Kesselman & Kesselman, Certified Public Accountants Tel Aviv, Israel 1309